Sintesis aspirin pdf download

Laporan praktikum ini merupakan kelanjutan dari laporan praktikum kimia organik yang pernah admin bahas minggu lalu, laporan ini admin susun dari berbagai sumber agar informasi yang di berikan lebih banyak. The risks of these events increase with increasing aspirin dose. Percobaan ini menghasilkan aspirin sebesar 2,2734 gram dengan berat rendemen sebesar 126,3%. On average, its systemic bioavailability is approx. Download laporan praktikum sintesis aspirin dan landasan teori mengenai aspirin lengkap dengan pembahasan dalam format pdf. Salicylic acid, the main metabolite of aspirin, is an integral part of human and animal metabolism.

By calculating the theoretical yield based on the original amount of salicylic acid, one could determine the actual yield percentage of the reaction. Synthesis of aspirin experiment chemistry libretexts. Aspirin given shortly after a heart attack decreases the risk of death. Aspirin merupakan antitrombik yang bekerja dengan cara mengasetilasi seecara irreversibel enzim siklooksigenase cox1 sehingga menghambat. We ask that users who download significant portions of the database cite the. Aspirin, also known as acetylsalicylic acid asa, is a medication used to treat pain, fever, or inflammation. Ester fenolat yang terbentuk adalah senyawa yang sudah dikenal dengan nama aspirin. Aspirin is absorbed in the stomach and small intestine, exerts its pharmacodynamic effect, for instance, the acetylation of a serine ser 529 residue of cox1 already in the portal blood, and is biotransformed to inactive salicylic acid by intestine, plasma, and liver esterases. This study was carried out to investigate the synthesis of aspirin derivatives from aspirin and aromatic compound of antioxidant and its biological activities.

Data are plotted from placebocontrolled aspirin trials in different clinical settings. Capitals indicate lifethreatening, underlines indicate most frequent. Aspirin level 1 aspirin level 2 aspirin level 3 aspirin level 4. The purity of the product will be confirmed by measuring its melting point range. Download laporan praktikum sintesis aspirin dan landasan teori mengenai aspirin lengkap dengan pembahasan. Aspirin acetylsalicylic acid is a painrelieving compound. Residual salicylate is considered a production contaminate and is not. The main site of platelets cox acetylation in the lowdose range of aspirin is portal blood, before the firstpass effect 15. Kenick organic chemistry fall 2009 green chemistry the objective of this project was to utilize green chemistry principles to synthesize aspirin. Sintesis ternyata lebih mudah dari yang diperkirakan, karena asilasi friedelcraft dari fenol paling baik dikerjakan dengan peramatam membuat ester fenolat dan menata ulangnya dengan alcl3. A read is counted each time someone views a publication summary such as the title, abstract, and list of authors, clicks on a figure, or views or downloads the fulltext. H 2 so 4 use a dropper, h 2 so 4 is highly corrosive and swirl the flask gently until the salicylic acid dissolves heat the flask gently on the steam bath for at least 10 minutes. Aspirin is also used longterm to help prevent further heart attacks, ischaemic strokes.

Efek antipiretik dan antiinflamasi salisilat terjadi karena penghambatan sintesis prostaglandin di pusat pengaturan panas dalam hipotalmus dan perifer di daerah target mycek, 2002. Report jurnal aspirin terjemahan please fill this form, we will try to respond as soon as possible. Aspirin continues to attract research and debate, 115 years after. Aspirin merupukan turunan dari asetil salisilat yang sangat berkhasiat, diantaranya berfungsi sebagai analgetik, antiseptic, penghambat pembentukan hormon, agen peuretik, agen untuk mengatasi sindrom batter.

Recently, it was elucidated that aspirin have anticoaggregatory effect in low dose. May 30, 2015 aspirin cepat dideasetilasi oleh esterase dalam tubuh, menghasilkan salisilat yang mempunyai efek antiinflamasi, antipiretik dan atau analgesik. It may also help treat pain from mild forms of arthritis. This article reveals about use of aspirin as antirheumatoid drugs and why therapeutic drug monitoring is needed in aspirin use sains medika, 42. Download the ios download the android app other related materials. Synthesis and biological activity of aspirin derivatives.

Aspirin akan larut ke dalam etanol karena bersifat polar dan aspirin akan membentuk kompleks berwarna ungu ketika ditambahkan fecl 3. The synthesis of aspirin chemistry science fair project. In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it. Do not lose this container or its contents, you will use them later. Aspirin screen experiment royal society of chemistry. On this page you can read or download retrosintesis aspirin in pdf format.

After eons of prehistory as folk remedy, aspirin emerged in 1899 in one of the worlds first industrial research laboratories. Dari sintesis aspirin maka terjadi reaksi antara asam salisilat yang di campurkan dengan anhidrida asam asetat maka cairan reaksi tersebut di tambahkan dengan 5 tetes asam sulfat dan di aduk dengan rata lalu di panaskan dengan suhu 8590c,maka cairan tersebut akan bercampur dengan rata akibat dari pemanasan tersebut. While in humans much of it is attributable to diet, a substantial part is synthesized endogenously. The twelve principles of green chemistry it is better to prevent waste than to treat or clean up waste after it is formed. It is the twostep synthesis of aspirin starting from oil of wintergreen. Aspirin hc9h7o4 or c9h8o4 cid 2244 structure, chemical names. Laporan praktikum kimia organik sintesis aspirin asam asetil. Tablet aspirin mengandung 325 650 mg asam salisilat. Pada minyak gandapura terdapat metil salisilat yang merupakan bahan dasar sintesis pengawet bahan makanan dan bahan dasar pembuatan obat sakit kepala aspirin sebesar 9699%.

Pada dosis 150 200mg kbb dapat terjadi intoksikasi akut sedang, dan dosis 300500 mg kbb akan menyebabkan intoksikasi berat. Berikut ini adalah download jurnal gratis yang merupakan kumpulan file dari berbagi sumber tentang jurnal pdf sintesis aspirin yang bisa bapakibu gunakan dan diunduh secara gratis dengan menekan tombol download biru dibawah ini. The synthesis of aspirin chemistry science fair project experiments, chemistry models, exhibition ideas, expo topics for kids and also organics chemistry science ideas for cbse, icse, middleschool, elementary school for 5th, 6th, 7th, 8th, 9th and high school students. A fixeddose combination of aspirin and dipyridamole. Lecture 01 introduction sintesis drug aspirin chemical. Selain itu juga untuk mensintesis polimer resin melalui senyawa antara asam salisilat asam2hidroksibenzoat. The present invention provides a method for the synthesis of acetyl salicylic acid comprising mixing acetic anhydride and salicylic acid in approximately or exactly stoichiometric proportions and calcium oxide or zinc oxide, obtaining a yield of a mixture of acetyl salicylic acid and calcium acetate or zinc acetate with 2% maximum of free salicylic acid content. Laporan praktikum pembuatan aspirin download file pdf. If not, then look for one of aspirins many cousins, pain killers that, despite their long and widespread usages, never cease to make headline news. Aspirin bekerja dengan menghambat agregasi trombosit sehingga menyebabkan terhambatnya pembentukan trombosit yang terutama sering ditemukan pada sistem arteri akbar. Acetaminophen is used to treat minor aches and pain and to reduce fever. Mar 04, 2014 tujuan dari percobaan ini adalah untuk melakukan sintesis aspirin dari asam salisilat dan anhidrat asetat dengan metode asetilasi.

Aspirin, also known as acetylsalicylic acid asa, is a medication used to reduce pain, fever, or inflammation. Oleh karena itu mengingat pentingnya cara pembuatan aspirin dalam kehidupan seharihari, maka dilakukan penelitian yang bertujuan untuk melakukan sintesis aspirin asam salisilat dan asetat glacial dengan metode asetilasi. From experience to design the science behind aspirin. Register this resource has been developed in partnership with learning science and the university of bristol this. The synthesis and characterization of aspirin part 1. Tujuan percobaan memahami reaksi esterifikasi fenol memahami reaksi pembuatan aspirin mampu melakukan uji kadar aspirin hasil reaksi 2. Dec 06, 2015 on this page you can read or download retrosintesis aspirin in pdf format. Synthesis of aspirin derivatives was prepared by esterification in the presence. Lecture 01 introduction sintesis drug free download as powerpoint presentation. The pd of aspirin pertains its interaction with and blockade of the active site of cox1 andor 2, being aspirin a nonselective inhibitor of both cox1 and 2 isoforms. Tinjauan pustaka esterifikasi adalah reaksi pengubahan dari suatu asam. The mechanism for this synthesis provides examples of three major classes of chemical reactions. Aspirin lacks the broad hydrogenbonded oh absorption that is prominent in oil of wintergreen and salicylic acid between 3000 and 3500 cm1.

Aspirin diuji kemurniannya dengan cara melarutkannya ke dalam etanol dan menambahkan tembaga ii klorida serta fecl 3. Us6278014b1 synthetic procedure for the manufacture of. Aspirin cepat dideasetilasi oleh esterase dalam tubuh, menghasilkan salisilat yang mempunyai efek antiinflamasi, antipiretik dan atau analgesik. Aspirin merupakan salah satu antitrombik yang lazim digunakan. Doc laporan praktikum kimia organik sintesis aspirin. One of the most consumed drugs production in the us is 10 million kgyear aspirin. Intoksikasi kronik dapat terjadi pada pemberian dosis lebih dari 100 mgkbb selama 2 hari atau lebih. Aspirin shelflife scenario download 38k pdf terrific science. Synthesis of aspirin ppt free download as powerpoint presentation. To synthesize acetylsalicylic acid aspirin, purify it, and determine the percent yield. The synthesis and characterization of aspirin part 1 purpose. It relieves your pain, reduces the inflammation swelling, and generally makes you feel better.

Synthetic methods should be designed to maximize the incorporation of. Aspirin was first isolated by felix hoffmann, a chemist with the german company bayer in 1897. Aspirin has been widely used as analgesic and antiinflammatory drug. Berikut ini adalah download jurnal gratis yang merupakan kumpulan file dari berbagi sumber tentang sintesis aspirin pdf yang bisa bapakibu gunakan dan diunduh secara gratis dengan menekan tombol download biru dibawah ini. Download materi plpg sertifikasi guru tahun 2016 terlengkap semua bidang studi gratis. Antiinflammatory inhibition of the synthesis of prostaglandins. Studies including a combination of aspirindipyridamole in human subjects. The reaction that is used for the synthesis is shown below. Laporan praktikum kimia organik sintesis aspirin asam.

Download laporan praktikum sintesis aspirin dan landasan teori mengenai aspirin lengkap dengan pembahasan dalam format lanjut baca. Description download jurnal aspirin terjemahan comments. Laporan praktikum sintesis aspirin dan landasan teorinya lengkap dalam format pdf, uji ini dilakukan untuk mensintesis aspirin. An experiment is described that is suitable for the early portion of the laboratory in a general chemistry course and integrates organic examples. Jan 21, 2014 aspirin was first isolated by felix hoffmann, a chemist with the german company bayer in 1897.

Aspirin, acetylsalicylic acid, is produced by the esterification of salicylic acid with acetic acid. On the other hand, whereas oil of wintergreen and salicylic acid have a single co absorption at about 1700 cm1, aspirin has two distinct peaks arising from its ester and acid co groups. H 2 so 4 use a dropper, h 2 so 4 is highly corrosive and swirl the flask gently until the salicylic acid dissolves. Take a small amount of the aspirin tablet and dissolve as much as you can in 3 drops of ethyl acetate. Synthesis of aspirin ppt green chemistry filtration. Specific inflammatory conditions which aspirin is used to treat include kawasaki disease, pericarditis, and rheumatic fever.